Biomedical and Pharmaceutical Engineering

Proc. of the Intl. Conf. on



Table of Contents



Biochips & Bioinstrumentation

Electrooculogram based Instrumentation and Control System (IC System) and its Applications for Severely Paralysed Patients
Adithya Rajan, R.G. Shivakeshavan and J. Vijay Ramnath

Rapid Differentiation of Pharmaceutical Biomolecules: Ginseng and Adulterants
Kevin Yi-Lwern Yap, Chu Sing Lim, Sui Yung Chan and Yew Weng Chan

Design and Rapid Constructions of Microstructures in Optical Fibers Using CO2 Laser-Their Potentials for Biosensor Application
Rudi Irawan, Swee Chuan Tjin, Chia Meng Tay and Khay Ming Tan

Electrochemical Study of A DNA Base Probe Based on Anticancer Drug Dacarbazine: A DNA Base Probe
Renyun Zhang and Xuemei Wang

The Effect of UV Irradiation on the Binding of Anticancer Drug Doxorubicin to DNA in the Presence of TiO2 Nanoparticles: Binding Drug to DNA
Min Song and Xuemei Wang

Evaluation of Speech Intelligibility for Feedback Adaptive Active Noise Cancellation Headset
Jiun-Hung Lin, Shih-Tsang Tang, Wei-Ru Han, Chih-Yuan Chuang, Ping-Ting Liu and Shuenn-Tsong Young


Biomedical Imaging & Visualization


Extraction of the Breast Cancer Tumor in Mammograms using Genetic Active Contour
GholamAli Rezaei Rad and Mehdi Kashanian

Automatic Gridding of Rotated Microarray Images
Christopher Le Brese and Ju Jia Zou

A Histogram-based Fast Enhancement Algorithm for CT Head Images
Jun Yin, Xiaolin Tian, Zesheng Tang and Yankui Sun

Retrospective Cluster Size Thresholding for MRF-based Detection of Activated Regions in fMRI
S. Suresh Anand and Vitali Zagorodnov

Statistical Surface Wavelets Model for Multiscale and Spatial-Localized Medical Image Analysis
Yang Li, Tiow-Seng Tan, Ihar Volkau and Wieslaw L. Nowinski

A Monopole Probe Loaded by Two Parasitic Elements for MRI 1.5 Tesla
Mohammad Mohammadzadeh and Seyed Alireza Ghasempour Shirazi

Modified Fuzzy Hopfield Neural Network Using for MRI Image Segmentation
Gholamali Rezai-Rad and Reza Valipour Ebrahimi

Automated Endocardial Boundary Detection using Dynamic Directional Gradient Vector Flow Snakes
Kirthika and Say Wei Foo

Accurate Extraction of Contour Information from the Cleavage of Neural Stem Cells
Chunming Tang and Jun Xu

FPGA Implementation of Real-time Fluorescence Endoscopy Imaging Algorithms
Cheong Lee Sing, Qian Kemao, Seah Hock Soon, Soo Khee Chee, Lin Feng, Patricia Thong, Yu Chin-Wen Kenneth and Malini Olivo

Discrimination between Alzheimer’s Disease and Control Group in MR-Images based on Texture Analysis using Artificial Neural Network
Meysam Torabi, Reza Dehestani Ardekani and Emad Fatemizadeh

Breast Cancer Diagnosis and Classification in MR-images using Multi-stage Classifier
Reza Dehestani Ardekani, Meysam Torabi and Emad Fatemizadeh

A Complete Automatic Region Growing Method for Segmentation of Masses on Ultrasound Images
S. Poonguzhali and G.Ravindran


Biomedical Signal Processing


Minimum Relative Entropy (MRE) Method for Fuzzy based Classification of Epilepsy Risk Levels from EEG Signals
R.Sukanesh and R.Harikumar

Speech-like Analysis of Snore Signals for the Detection of Obstructive Sleep Apnea
Andrew K. Ng, T.S. Koh, Eugene Baey and K. Puvanendran

Developing Hidden Markov Models for Aiding the Assessment of Preterm Babies’ Health
Dominic S. Lee, James Roscoe and Glynn Russell

A Novel Pattern Recognition Technique for Quantification of Heart Rate Variability
V.I. Thajudin Ahamed, P. Dhanasekaran, N.G. Karthick, Paul K. Joseph, A. Naseem and T.K. Abdul Jaleel

Tracking the Left Ventricular Motion by Harmonic State Model
Lionel Evina, Mohammed Oumsis and Mohammed Meknassi

Localisation of Epileptic Seizures by - A Novel Technique Topographical Brain Electrical Activity Mapping
D. Najumnissa and S. Shenbagadevi

EEG Signal Analysis Based on Time-variant Coupled Network Lattice Model
Minfen Shen, Guoliang Chang, Shuwang Wang and Patch J. Beadle

Estimation of Visual ERP Signals with Nonextensive Entropy
Minfen Shen, Bin Li and Hongrong Tang

Prediction of Active Substance Content in Pharmaceutical Tablets Using Wavelet Compressed NIR and Raman Spectroscopic Data
C.S. Soh and P. Raveendran

Changes in Cardiopulmonary Coupling During Sleep Onset
C.-P. Chua and C. Heneghan

Heart Rate Variation for Iodinated Contrast Medium Injection Based on Adaptive Template Matching Algorithm
Kang-Ming Chang, You-Cyuan Su, Shing-Hong Liu, Shi-Chung Yang and Yu-Ling Li

Evaluation of Feature Selection Methods for Improved EEG Classification
Akram AlSukker and Ahmed Al-Ani

Baseline Wandering Removal by Using Independent Component Analysis to Single-Channel ECG data
Zeinab Barati and Ahmad Ayatollahi

Combination Of Multiple Classifiers With Fuzzy Integral Method for Classifying The EEG Signals in Brain-Computer Interface
Zahra Shoaie, Maryam Esmaeeli and Saeed Bagheri Shouraki

Comparing Higher Order Statistics Of Three ICA Methods In Wavelets-based Single-channel Fetal ECG Extraction
Mehdi Poursoltani, Ameneh Boroomand and Ahmad Ayatollahi

VLSI Design and Simulation of A SIRM Fuzzy System - Diabetic Epilepsy Risk Level Classifier –A Case Study
R. Sukanesh, K. Gunavathy, R. Harikumar and K. Paramasivam

Image Denoising Based on A Mixture of Bivariate Gaussian Distributions with Local Parameters in Complex Wavelet Domain
Hossein Rabbani, Mansur Vafadust and Saeed Gazor

Some Limitations of Localizing Inert Region from EEG
Masato Katayama, Masatake Akutagawa, Udantha R. Abeyratne, Yoshio Kaji, Fumio Shichijo, Hirofumi Nagashino and Yohsuke Kinouchi


Biomechanics


Influence of Colour Hue on Fractal EEG Dimensions
Jagdish Tripathy, Franz Konstantin Fuss, Vladimir V. Kulish and Site Yang

Design and Development of an Earthquake-Simulated Environment for the Study of Postural Stability
Z. O. Abu-Faraj, T. F. Hamdan, M. R. Wehbi, G. A. Khalil and H. M. Hamdan

Dynamic Intrameniscal Stresses Measurement in the Porcine Knee
P. K. Goh, F. K. Fuss, T. Yanai and A. C. Ritchie

Using Sole Pressure Signals to Analyze Walking Posture
Yasuhiro Okazaki, Norihiko Yoshida and Kimio Oguchi

Effect of Vibration on Lumbar Bone of OVX Rats compared with Risedronate-dosed Rat
Chang Yong Ko, Tae Woo Lee, Dae Gon Woo, Bum Seok Namgung, Han Sung Kim and Beob Yi Lee

Finite Element Analysis of Head-neck Kinematics Under Rear-end Impact Conditions
Ee Chon Teo, Qing Hang Zhang and Tian Xia Qiu

Time-Dependent Change of Load Sharing between Two Non-Linear Visco-Elastic Materials: Experiment and Model
F. K. Fuss, P. K. Goh, T. Yanai and A. C. Ritchie

Status Review on Human Reproduction Biomechanics
Foo Jong Yong Abdiel and Lim Chu Sing

CT Based Three Dimensional Finite Element Model of Cervical Spine
Swapna Basa and Venkatesh Balasubramanian

On Preconditioning and Stress Relaxation Behaviour of Fresh Swine Skin in Different Fibre Direction
Zizhen Liu and Kristy Yeung

Design and Mechanics of TLIF/ELIF Implants
Franz Konstantin Fuss and Ronald J. Sabitzer

Biomechanical Tests of Osteoporotic Vertebral Trabecular Bone using Finite Element Analysis Based on Micro-CT
Dae Gon Woo, Tae Woo Lee, Chang Yong Ko, Han Sung Kim and Ye-Yeon Won


Biochips & Bioinstrumentation and Bionanotechnology & Bio MEMS


Monitoring and Measuring Instrument Design of RF Electromagnetic Fields for Human Physical and Mental Health
Chih-Yuan Chuang, Jiun-Hung Lin, Shih-Tsang Tang, Wei-Ru Han, Ping-Ting Liu and Shuenn-Tsong Young

Wireless Health Alert and Monitoring System
Arun Kumar and Fazlur Rahman

Noninvasive Estimation of Tissue Impedance Based on an Equivalent Circuit Model
Yuichi Ikeda, Yasuhiro Sato, Yohsuke Kinouchi, Emiko Yasuno, Yuken Omine, Akira Tangoku and Tadaoki Morimoto

Fabrication and Performance Testing of Disposable Micropump Suitable for Microfluidic Chip
Rudi Irawan, Sundaram Swaminathan, Paul Aparajita and Swee Chuan Tjin

Design and Development Of a Simple Hardware Setup for Sensing Blood Volume Pulse and a PIC Microcontroller Based Heart Rate Meter
V.K. Jayasree, V.P.N. Nampoori, P. Radhakrishnan and C.P. Girijavallabhan

Nanocomposite Bone Tissue-Engineering Scaffolds Prepared from Gelatin and Hydroxyapatite using Layer Solvent Casting and Freeze-Drying Technique
Mahmoud Azami, Fariba Orang and Fathollah Moztarzadeh


Bionanotechnology & Bio MEMS and Tissue Engineering


Encapsulation of DNA by Cationic Copolymer Vesicles for Gene Delivery and Micro-arraying Techniques
Wong Chee Keong Benjamin

Thermo-Responsive Hydrogel-Coated Gold Nanoshells
Jun-Hyun Kim and T. Randall Lee

Preparation and Characterization of Poly-ε- caprolactone Carrier Particles for controlled Insulin Delivery
A. Mukerjee, V. Pruthi and V. R. Sinha

Adhesion of Tooth Germ Cells on Various Biomaterials
Rung-Shu Chen, Tai-Horng Young and Min-Huey Chen

Interactions of HepG2 Cells on Biomaterials with Various Surface Properties
Jui-Nan Lu and Tai-Horng Young

Porcine Small Intestinal Submucosa is a Suitable Small Diameter Vascular Substitute
W.C. Toy, Y.Y. Gan, S.K. Law, J.H. Yeo, J.J. Chiu, L. J. Chen and H.C. Hwang


Biomedical Imaging & Visualization and Drug Discovery & Design


Incorporation of Active Contour Without Edges in the Fast Level Set Framework for Biomedical Image Segmentation
Annamalai Lakshmanan, Myo Thida, Kap Luk Chan and Jiayin Zhou

Temporal and Antigenic Analysis of Dengue Virus Serotype 1 Genome Polyprotein Sequences
Menaka Rajapakse, Anitha Veeramani, Kavitha Gopalakrishnan, Sivagami Ananthanarayan, K. N. Srinivasan, J. Thomas August, Asif M. Khan and Vladimir Brusic

Performance Evaluation of MULTIEPD1 on Prediction of MHC Class I Binders
Guang Lan Zhang, J. Thomas August, Chee Keong Kwoh and Vladimir Brusic

Grinding Effect on the Thermodynamic and Kinetic Characterizations of Polymorphic Transformation of Famotidine
Shan-Yang Lin, Wen-Ting Cheng, Mei-Jane Li and Shun-Li Wang

Computational Models for Identifying Promiscuous HLA-B7 Binders based on Information Theory and Support Vector Machine
Guang Lan Zhang, Joo Chuan Tong, Zong Hong Zhang, J. Thomas August,Yun Zheng, Chee Keong Kwoh and Vladimir Brusic

BioDArt – Catalogue of Biological Data Artifact Examples
Anitha Veeramani, Kavitha Gopalakrishnan, Vladimir Brusic and Judice L.Y. Koh


Biomechanics and Bioinformatics & Computational Biology


Biomechanical Effects of the Weight of Side Loaded Carriage in Walking - Correlation between Body Center of Mass (COM) and Joint Moments
Hyunho Choi, Sungjae Hwang, Yongkun Cho, Sungsik Myung, Hansung Kim and Youngho Kim

FE Assessment of an Interspinous Implant (ISS)
Yuanli Zhou, Tianxia Qiu, Ee Chon Teo and Dominique Petit

Discussions of Knee Joint Segmentation
Y. Sun, E.C. Teo and Q.H. Zhang

A Relevance Vector Machine Based Quantitative Prediction Method for Mouse Class I MHC Peptide Binding Affinity
Dingfang Li and Wenchao Hu

Predition of Shared Regulatory Motifs from Upstream DNA Database for Gallus Gallus
Kwoh Chee Keong and Tan Chee Hian

A Prognosis Tool based on Hemostasis and Genetic Complementary Learning
T.Z. Tan, G.S. Ng, C. Quek and S.C.L. Koh


Biooptics & Biosensing


Fluorescence Lifetime Imaging of Haematoxylin and Eosin-stained Cervical Tissue
C.Y. Fu, U.S. Dinish, B.K. Ng, V.M. Murukeshan, L.K. Seah and S.K. Lim-Tan

Detection of DNA Sample Fluorescence Using Frequency Domain Imaging Technique
U.S. Dinish, L.K. Seah, V.M. Murukeshan, H. Gong and N. Ramalingam

ZnO/TiO2 Core-Shell Quantum Dots Application for Colorectal Cancer Fluorescence Image
S. Fu, C.S. Lim, L.C. Kwek, T.C. Chia and C.L. Tang

Rapid Palm Sized-All in One Tuberculosis Screening System
A.M. Pariwono, C.S. Lim, S.T. Lo, Y. Amrie and A. Muchtar

Rapid Porcine Diagnostic System (RPDS) for Detecting PRRS Antibodies in Swine Blood Sera
P.V. Preejith, P.C. Yip, C.E. Lim, T.H. Zhing and C.S. Lim

Development of an Ultra-high Sensitive Fluorescence Measurement System for Cancer Research
Rie Yamada, Masahiro Kohno and Motohiro Takeda

Application of Self-Assembled Monolayer of Carboxy-1-Decanthiol for Cholesterol Biosensor
Pratima R. Solanki, Sunil K. Arya, B.D. Malhotra, Y. Nishimura and M. Iwamoto

Serum Albumin Measurement Using a Tapered Fluorescent Fiber-optic Evanescent Wave-based Biosensor
P.V. Preejith, C.S. Lim and T.F. Chia


Assistive & Rehabilitation Technology


Recurrent Neural Network Control of Functional Electrical Stimulation Systems
Wu Yilei, Song Qing, Yang Xulei and Lan Li

Improvement of Esophageal Speech using LPC and LF Model
Ratchanok Sirichokswad, Pornchai Chanyagorn, Warakorn Charoensuk, Panuthat Boonpramuk, Nittaya Kasemkosin and Harold H. Szu

Ground Truth Estimation using Multimodal Data Fusion
P. Mohan, W.S. Ng and D. Shi

Effect of LBP on Muscle Activity of Lower Back and Upper Extremity While Aerobic Cycling – An sEMG Based Study
J. Srinivasan and Venkatesh Balasubramanian

Development of an Active Ankle Foot Orthosis for the Prevention of Foot Drop and Toe Drag
Sungjae Hwang, Jungyoon Kim, Jinbock Yi, Kisik Tae, Kihong Ryu and Youngho Kim


Biomedical Signal Processing and Cardiovascular & Respiratory Systems


Music and the EEG: A Study using Nonlinear Methods
N.G Karthick, V.I. Thajudin Ahamed and Paul K. Joseph

Analysis of the Characteristics of Electrooculogram Applied a Battery Model to the Eyeball
Kayo Shinomiya, Hiroshi Shiota, Yaeko Ohgi, Nobuyuki Itsuki, Ray Tabesh, Masashi Yamada and Masanori Kubo

A Strong Adaptive and Comprehensive Evaluation of Wavelet Based Epileptic EEG Spike Detection Methods
Reza Sarang

Measurement of Blood Flow Velocity Waveforms in the Carotid, Brachial and Femoral Arteries during Postural Change
Azran Azhim, Mizuki Katai, Masatake Akutagawa, Yuji Hirao, Kazuo Yoshizaki, Shigeru Obara, Masaharu Nomura, Hiroyuki Tanaka, Hisao Yamaguchi and Yohsuke Kinouchi

Normalized Pulse Transit Time to Assess Age-Related Changes
Foo Jong Yong Abdiel and Lim Chu Sing


Targeted Drug & Gene Delivery


Ultrasound Mediated Gene Delivery using Bubble Containing Lipoplexes
Jun Hua Mai, Rui Liu, Xiaohui Wei, Yanbin Yao and Yuhong Xul

Peptide Ligand Targeted Delivery to EGFR Expressing Cancer Cells in Vitro and in Vivo
Shu-xian Song, Dan Liu, Jin-liang Peng and Yu-hong Xu

The use of Nano-structured Hybrid Materials for Oral Drug Delivery
Rajendra Kumar, Philip Cheang, Kithva Prakash Hariram and Khor Khiam Aik

Low Molecular Weight Chitosan-Based Conjugate: A New Platform for Oral Delivery of Paclitaxel
Eunhye Lee, Jinju Lee and Sangyong Jon


Cardiovascular & Respiratory Systems


Continuous Measurement of Oxygen Saturation Level using Photoplethysmography Signal
Gazi Maruf Azmal, Adel Al-Jumaily and Moha’med Al-Jaafreh

Particle Swarm Optimization based Stroke Volume Influence on Mean Arterial Pressure
Moha’med O. Al-Jaafreh and Adel A. Al-Jumaily

A Simulation Study of Arrhythmia using Computational Model
R. Malathi and M. Ramasubba Reddy

Exercise Training Improved Blood Flow Velocity and Autonomic Nervous Activity
Azran Azhim, Mizuki Katai, Masatake Akutagawa, Yuji Hirao, Kazuo Yoshizaki, Shigeru Obara, Masaharu Nomura, Hiroyuki Tanaka, Hisao Yamaguchi and Yohsuke Kinouchi

Blood Flow Velocities in Common Carotid Changes with Age and Exercise: Study by Using of Telemetry Method
Azran Azhim, Mizuki Katai, Masatake Akutagawa, Yuji Hirao, Kazuo Yoshizaki, Shigeru Obara, Masaharu Nomura, Hiroyuki Tanaka, Hisao Yamaguchi and Yohsuke Kinouchi

Frequency Domain Analysis of ECG Signals using Auto-Associative Neural Networks
Atul Sethi, Siddharth Arora and Abhishek Ballaney

Superoxide Detection by Chemiluminescence, Fluorescence, and Spectrophotometry Methods
Anindya P. Susanto, Mohammad Firdhaosh, Wang Dong-An and Moe Kyaw Thu


Bioinformatics & Computational Biology


Comparative Genomic Analysis Suggests FOXP3 Facilitates Tumor Evasion against Immunosurveillance by Transcriptionally Up-regulating Proteinase Inhibitor 9
Xinguo Jiang, Jun Cai and Sheng Zhong

Cross-correlation of DNA Sequences Using Hypercomplex Number Encoding
Yajing Li and Jian-Jun Shu

Proteomic Analysis of Ginseng
Jian Min Yeh, Jocelyn Wan-Yin Ong and Kevin Yi-Lwern Yap

A Tale of Intronless Genes in Eukaryotic Genomes
Meena Kishore Sakharkar, Li Yu, Iti Chaturvedi and Li Peng

A Computational Model of Ferrofluid Flow using Maxwell’s Equations and Navier-Stokes Equations
M. Lohakan, C. Yensiri, S. Boonsang and C. Pintavirooj

A Genomic Level Analysis of Alcohol Producing Pathways of Zymomonas mobilis
A.P. Ranjan, C.S. Prasad, G.P. Agarwal and S. Ramachandran

Design and Implementation of An Intelligent Agent System for Genome Data Retrieval
F. Sufi, I. Cosic and Q. Fang

GeneONE Portal Framework for integrating Genome Databases, tools, techniques and methods
G. Mohamed Hanifa and Lee Sai Peck


Biomaterial & Biomolecular and Cognitive Neuroscience & Neurosystems


Cellular Uptake Enhancement of Polyamidoamine Dendrimer Modified Single Walled Carbon Nanotubes
Bifeng Pan, Daxiang Cui, Ping Xu, Tuo Huang, Qing Li, Rong He and Feng Gao

Modeling of Thermal Gelation and Degelation of MC and HPMC Hydrogels
S.C. Joshi, Y.C. Lam, B.K. Tan and S.Q. Liu

Bistable Behavior in A Pair of Interacting Autorhythmic Cardiac Cell Models: Implications to Cardiac Memory
G. Sachdeva, J. Krishnan and V.S. Chakravarthy

Dynamic Complexity of Cognitive Event-related Potential Based on Time-dependent Approximate Entropy
Nan Zhao, Supin Wang, Xiaofeng Liu and Mingxi Wan


Assistive & Rehabilitation Technology and Biorobotics, Surgical Robotics & Surgical Planning


Rapid On-Site Method to Screen Actinobacillus Pleuropneumoniae in Life Porcines
A.M. Pariwono, A.L. Chan, and P.C. Yip

High Intensity Ultrasound Phased Array for Surgical Applications
Meng Tong Tan, Chang Min Chu and Sunita Chauhan

Modeling and Analysis of Human Spinal Feedback Control System
Lan Li, Zhu Kuanyi and Wu Yilei

Ergonomic Master Controller for Flexible Endoscopic Gastrointestinal Robot Manipulator
Z.M. Thant, S.C. Low, S.W. Tang, L. Phee, K.Y. Ho and S.C. Chung


Bioinformatics & Computational Biology and Distributed Diagnosis & Home Healthcare


Validating Text Mining Results on Protein-Protein Interactions Using Gene Expression Profiles
Deyu Zhou, Yulan He and Chee Keong Kwoh

The First Steps Towards Bone Plate Morphing: A Finite Element Model Of A Bone Plate With A Micro Scratch
A.C. Van Der Zanden and C.S. Lim

Web Service-based Healthcare Information System (WSHIS): A Case Study for System Interoperability Concern in Healthcare Field
J.K. Zhang and W. Xu

Design and Implementation of Expert-Telemedicine System for Diabetes Management at Home
Rudi Rudi and Branko G. Celler

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