The purpose of this paper is to propose a sophisticated framework of Risk- Informed and Performance-Based (RIPB) seismic design. The proposed design system considers the concept of Defence-In-Depth (DID) and robustness in addition to the consideration of failure probability of each Structure, System and Component (SSC) against seismic motion. Importance and significance of the RI-PB design have been realized in Japan after the Fukushima nuclear accident. However, there are not any specific and practical design procedures based on RI-PB concept which have been applied to actual nuclear facilities. One of the main characteristics of the proposed framework is to consider system characteristics such as system diversity and system redundancy from the beginning of the design stage according to the PRA results. Furthermore, robustness toward the different types of earthquakes is considered by means of evaluation of failure probability of system based on the correlation of seismic motion spectrum. DID which is the most important concept of nuclear safety is also considered as a balance of risk profile. This paper describes the characteristics of the proposed framework including the results of some case studies regarding the feasibility of the framework.