Natural and manmade disasters have been extensively studied especially regarding the hazards' parameters and the infrastructure systems' or networks' vulnerability and resilience. While several of these studies have identified the significance of the social factor, the attempts to model it were insufficient so far. This paper presents a systematic study on the relation between behavioral factors, behavioral patterns and humans' reaction during catastrophic events. The paper presents evidence, which documents the lack of direct modeling of the human behavior aspect during catastrophic events. As literature shows, the various existing approaches introduce the social aspect into resilience assessment mainly in the form of an index or, indirectly, as a parameter introduced in the modeling of other problem's variables. The paper, also, identifies and classifies human reactions during catastrophic events and the causes for them. Three general patterns are identified, namely reflex, panic and controlled behaviors. The research methodology concludes with a questionnaire survey that is designed and executed to explore the relation between the behavioral factors and the behavioral patterns and humans' reactions during catastrophic events. The statistical analysis of the collected data reveals that, contrary to the expectations, there is no significant correlation between behavioral factors and patterns during catastrophic events. This finding may indicate the need for a different approach in this course of research.